Circulating
Intelligence

FROM FRAGMENTS TO CLINICAL INTELLIGENCE

Small
fragments.
Big picture.

We’re building a foundation model to turn cell-free DNA data into clinical intelligence. Bring your data, your clinical questions, or your expertise.

↗
Build with us
DATA → FOUNDATION → POSSIBILITIES01 / CI
A sea of fragments.
A world of possibilities.
CONCEPTUAL VIEW
NOT PATIENT DATA

01 / OUR APPROACH

Your data.
Our shared foundation.

A single dataset can help answer a specific question. Learning across datasets could unlock many more.

We’re bringing together cfDNA data and clinical expertise to learn the biology shared across diagnostic questions. Our aim is to give each new application a stronger starting point.

01

Bring diverse data.

We’re seeking cfDNA sequencing datasets, linked clinical outcomes, and partners with samples or cohorts to explore together.

02

Learn the common biology.

We’re developing a foundation model that learns patterns across samples, conditions, and datasets, so that new applications can share what it learns.

03

Develop clinical intelligence.

Together with clinical and diagnostic partners, we want to adapt and evaluate that foundation against questions that matter in care.

ONE FOUNDATION. MANY POSSIBILITIES.

Clinical intelligence.
In many directions.

We want to build a foundation for a wide range of blood-based diagnostics. These are the questions we want to explore with partners.

One cfDNA
foundation model
SHARED BIOLOGY
01

Disease detection

Can we identify a signal of disease earlier?

02

Tissue of origin

Where in the body is a signal coming from?

03

Disease characterisation

Which biological differences could matter for care?

04

Treatment response

Is a treatment having the intended effect?

05

Residual disease

Is a disease signal still present after treatment?

06

Recurrence monitoring

Is a disease signal returning over time?

Potential applications to develop and validate with collaborators.

02 / THE PEOPLE BEHIND THE QUESTION

Biology.
Machine learning.
Clinical ambition.

Founded by Duco Gaillard, a PhD researcher at the Netherlands Cancer Institute and TU Delft, Circulating Intelligence brings together cfDNA fragmentomics and foundation-model research.

We are developing the technology and building collaborations to test it against meaningful clinical questions.

DATA. QUESTIONS. PEOPLE.

What could your
data make possible?

We’re looking for collaborators who want to build the next generation of clinical intelligence with us.

Data & sample partners

Biobanks, cohort teams, sequencing labs, and researchers with cfDNA data or samples.

Discuss a dataset

Researchers & builders

People working across machine learning, genomics, and translation who want to contribute.

Start a conversation